The server hosting my exchange account had a major hardware failure last week that eventually resulted in a full rebuild and restore. I was without email for 3 days. No major complaints and in the end, I didn't lose anything.
The only issue: somehow my Outlook / Exchange based RSS feeds failed to re-sync after the restore. These were already very flakey and I was already giving serious thought to moving back to News Gator. The server failure and subsequent syncing issues only pushed me over the edge. I really tried to make the Microsoft solution work but in the end, I just couldn't handle it any more.